Ribosomal Lesions Promote Oncogenic Mutagenesis
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چکیده
منابع مشابه
Atomic mutagenesis at the ribosomal decoding site
Ribosomal decoding is an essential process in every living cell. During protein synthesis the 30S ribosomal subunit needs to accomplish binding and accurate decoding of mRNAs. From mutational studies and high-resolution crystal structures nucleotides G530, A1492 and A1493 of the 16S rRNA came into focus as important elements for the decoding process. Recent crystallographic data challenged the ...
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With a diameter of ~30 nm and a mass of ~4.3 MDa, human ribosomes are structurally and functionally sophisticated cytoplasmic giants. Half of this mass comes from the 81 ribosomal proteins (RPs) which, formerly erroneously believed to simply act as dispensable assistants of the catalytic ribosomal RNA (rRNA), are in many cases essential for ribosomal functioning. Ribosomes can mechanistically b...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2018
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-18-1987